Product Name: Paroxetine
Synonyms: 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,( 57364885, 57186608,3s,4r)-piperidin;3α-(1,3-Benzodioxole-5-yloxymethyl)-4β-(4-fluorophenyl)piperidine;3α-[(1,3-Benzodioxol-5-yl)oxymethyl]-4β-(4-fluorophenyl)piperidine;(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)piperidine;Paroxetine HCl anhydrous API;Paloxitene;Piperidine,3-[(1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)-,( 57364886, 57186609,3S,4R)-;(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
CAS: 61869-08-7
MF: C19H20FNO3
MW: 329.37
EINECS: 682-717-4
Product Categories: Fluorobenzene;APIs;Paroxetine;Inhibitors;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;API's
Mol File: 61869-08-7.mol
Paroxetine Structure
Paroxetine Chemical Properties
Melting point 114-116°C
density 1.1844 (estimate)
pka pKa 9.51 (Uncertain)
CAS DataBase Reference 61869-08-7(CAS DataBase Reference)
NIST Chemistry Reference Paroxetine(61869-08-7)
EPA Substance Registry System Piperidine, 3-[(1,3-benzodioxol-5-yloxy) methyl]-4-(4-fluorophenyl)-,( 57364887, 57186610,3S,4R)-(61869-08-7)
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
MSDS Information
Paroxetine Usage And Synthesis
Description Paroxetine is a new highly selective serotonin reuptake inhibitor, mechanistically similar to fluoxetine, fluvoxamine and sertraline, introduced for the treatment of all types of depressive illnesses including depression associated with anxiety. It is reportedly non-sedating and non-stimulatory and compared to fluoxetine has a shorter duration of action (half-life of 24 hours versus 2 to 3 days). Paroxetine is also being investigated as a treatment for obesity, alcoholism and obsessive-compulsive disorders.
Chemical Properties White Solid
Originator As Ferrosan (Novo-Nordisk) (Denmark)
Uses A istopically labelled selective serotonin reuptake inhibitor. Used as an antidepressant
Brand name Paxil[as hydrochloride] (SmithKline Beecham);Seroxat.
General Description In the structure of paroxetine (Paxil), an amino group, protonatedin vivo could H-bond with the–CH2–O– unshared electrons.A β-arylamine–like structure with an extra aryl groupresults. The compound is a very highly selective SERT. Asexpected, it is an effective antidepressant and anxiolytic.